British Air Force Typhoon FGR4s have joined forces with French aircraft in a joint strike on an underground arms cache in Syrian territory used by the IS group, according to the UK Ministry of Defence.
The site, located using intelligence, was believed to be housing weapons and explosive materials, the announcement noted, and was situated in mountainous terrain just north of Palmyra in the heart of Syria.
"Our aircraft employed precision-guided Paveway IV munitions to target a several approach shafts leading to the depot... preliminary assessments are that the target was engaged successfully," officials stated.
There was no sign of any civilian impact in the operation late on Saturday and each participating jet made a safe return, the MoD added.
The Typhoon FGR4s were supported by a Voyager aerial refuelling aircraft.
IS - referred to as Daesh - established extremist governance over parts of Iraq and Syria prior to its 2019 collapse.
"This action underscores British leadership, and resolve to operate in unison with allied nations, to eliminate any re-emergence of Daesh and their harmful and extremist ideologies in the area," UK Defence Secretary the minister stated.
British military aircraft have conducted overwatch operations over Syria to "forestall any attempted comeback" of the group following its routing at the Baghuz confrontation in 2019, the ministry said.
"I want to thank all the members of the UK armed forces who took part in this strike for their professionalism and their valour," the Defence Secretary added. "They were among a great many British troops deployed over Christmas and New Year. This mission, to take out dangerous terrorists who threaten our security, demonstrates how UK forces are prepared to act, continuously, keeping Britain secure domestically and strong abroad."
In December, the American forces executed what it called a "massive strike" targeting Daesh sites in Syria, subsequent to an attack killed two US servicemembers and a local interpreter in Palmyra.
The United Nations reports Islamic State still boasts roughly 5-7 thousand fighters in Syria and Iraq.